Articles tagged with "Alzheimer’s and Dementia"


  • The Empowering Neurologist – David Perlmutter, M.D., and Dr. Lisa Mosconi

    David Perlmutter M.D. – Empowering Neurologist: The food, the facts, the science to control your genetic destiny. Why are most Alzheimer’s patients women? It may come as a surprise to you, but women outnumber men when it comes to Alzheimer’s disease sufferers by a ratio of 2 to 1. Why Alzheimer’s affects women so adversely is unclear, but we do know there is a lot of science that’s beginning to make sense of this statistic. Moreover, now that we are gaining ground on understanding why the female brain is more susceptible to this devastating disease, it allows us to begin getting our arms around the idea that specific lifestyle changes may be very important as they relate to reducing a woman’s risk. In her new book, The XX Brain, my good friend, Dr. Lisa Mosconi, takes us to the leading edge of neuroscience research, revealing how differences between the male and female Read More

  • Alzheimer’s and Exercise – You Can Protect Your Brain

    David Perlmutter M.D. – Empowering Neurologist: The food, the facts, the science to control your genetic destiny. The number of Americans diagnosed with Alzheimer’s disease has continued to grow at a dramatic rate. Currently, it is estimated that some 5.8 million Americans (of all ages) have Alzheimer’s disease. By and large, this is a disease of elderly individuals, with approximately 5.6 million of those diagnosed age 65 or older. To put that number into context, consider that this means 1 in 10 people age 65 or older suffers from Alzheimer’s disease. Further, it is instructive to note that there are some 200,000 individuals here in America under age 65 years who have also been given the diagnosis. Despite heroic research efforts, Alzheimer’s remains a disease for which there is no cure or meaningful treatment whatsoever. That said, it is critical that we ask ourselves if there is any evidence that Read More

  • Your Alzheimer’s Prevention Program – Start Today!

    David Perlmutter M.D. – Empowering Neurologist: The food, the facts, the science to control your genetic destiny. It’s relatively straightforward – the best time to do something about fending off Alzheimer’s disease and dementia is well before you start to experience warning signs of cognitive decline. As has been well-documented on this blog before, inflammation in your 20s, 30s, 40s…really, at any stage in life, has been associated with increasing your risk for Alzheimer’s disease, a disease for which there is no cure. As we’ve been preparing and launching our docuseries on Alzheimer’s, Alzheimer’s: The Science of Prevention, I’ve been reminded of the importance of this, and the relationship between Alzheimer’s and inflammation, thanks to the information shared by the experts taking part in this series. So today I want to review some recent science that shows just how powerful that relationship has been revealed to be. The post Your Read More

  • How to Lower Risk for Brain Amyloid

    David Perlmutter M.D. – Empowering Neurologist: The food, the facts, the science to control your genetic destiny. It is well-documented that the accumulation of the beta-amyloid protein in the brain is correlated with Alzheimer’s disease. Ongoing research seeks to understand how, and at what stage of Alzheimer’s, beta-amyloid proteins influence the disease. What we can be certain of is that reducing levels of beta-amyloid accumulation, and preventing accumulation in the first place, is something we should be striving for in the pursuit of optimal brain health. Doing so means understanding what causes beta-amyloid accumulation in the first place. A study in the journal Nature looked at one specific factor, insulin resistance, to understand its role, and also considered it in the context of whether or not the research subject was a carrier of the APOE4 gene. The results are illuminating with regard to what they tell us about the significance Read More

  • Coffee – Good for Your Brain!

    David Perlmutter M.D. – Empowering Neurologist: The food, the facts, the science to control your genetic destiny. There has certainly been a lot of information appearing in scientific literature as of late indicating that coffee consumption is good for the brain. One recent report has revealed what I believe to be a very specific mechanism that directly relates the consumption of coffee to the well-established reduction in risk for Alzheimer’s disease (AD). Researchers in Toronto, Canada, recognizing that coffee consumption is correlated with the decreased risk of Alzheimer’s disease, set about to unravel the specific mechanism whereby coffee is neuroprotective in humans. They explored whether certain compounds found in brewed coffee can protect the brain by reducing the aggregation, or clumping, of specific proteins that occur in the brain. The aggregation of these two proteins, amyloid-beta (Aβ) and tau, seems to set the stage for brain degeneration. When this aggregation Read More

  • Implications of the “Alzheimer’s Gene” in Children

    David Perlmutter M.D. – Empowering Neurologist: The food, the facts, the science to control your genetic destiny. The development of highly accurate and widely available genome sequencing technology has put us at a crossroads. Now, more than ever, the divergent views of nature versus nurture confront consumers wishing to be advocates for their own health. As we learn about our genetics it seems quite clear that the deterministic message about our health destiny is ringing loud and clear. More and more, the idea that we are at the mercy of our inheritance seems supported by the advancing understanding and interpretation of our individual genetic profiles. An important message we have been espousing over the past decade centers on the importance of lifestyle choices, specifically directed to offset disease risk that may well be enhanced by genetics. This ideology centers on the notion of genetic predisposition in contrast to genetic determinism. Read More

  • Gut Bacteria and Their Role in Depression

    December of 2019 marks the publication of a new medical textbook, The Microbiome and the Brain (CRC Press). The text features chapters focused on a number of important topics, among them the role of gut bacteria in a variety of medical conditions including autism, multiple sclerosis and Alzheimer’s disease. The common theme throughout the book, as one would surmise from the title, is the relationship between the gut and brain health. The chapters have been written by some of the most well respected researchers and clinicians from around the world, and I am honored to be the editor-in-chief of this important contribution. One area in which the relationship between the gut and the brain that seems to be getting a lot of attention as of late focuses on how variations in the gut bacteria may ultimately contribute to alterations in mood. Specifically, there is currently a fairly in-depth pursuit to Read More

  • Even Mild Exercise Helps the Brain

    An important part of my lectures over the past several years has been to emphasize how our lifestyle choices, around things like sleep, diet, and exercise, will ultimately impact the destiny of our brains. For example, we have long been discussing how exercising today relates to a healthy brain in the future, especially its association with reduced risk for dementia. Now, new data is revealing that exercise not only has long-term benefits for brain health, but even more acute changes are being discovered that are clearly positive. In their recent publication in the journal PNAS, Japanese researchers, with the accepted premise that physical exercise does benefit how the brain works, wanted to determine some specifics about just how much exercise is required for it to positively impact the brain. Their human research utilized some very sophisticated, high-resolution MRI brain scanning techniques that are able to delineate the functionality of the brain’s Read More

  • Vitamin D and Alzheimer’s Disease: Could Deficiency Increase Your Risk?

    You know, we’ve explored, several times now, the relationship between vitamin D levels and risks for severe health complications, including dementia. Notably, my colleague Dr. Dale Bredesen has written and researched much on this topic, particularly with regard to the relationship between vitamin D levels and Alzheimer’s risk. In fact, Dr. Bredesen even includes vitamin D supplementation in his protocol for treating Alzheimer’s and dementia. Well, a new study in the journal Neurology explores the scientific fact behind this relationship between vitamin D, and dementia and Alzheimer’s. This longitudinal study followed 1,000+ elderly individuals who were free of dementia at the outset, to see how their vitamin D levels and brain health state changed over time. Here’s what they found. Source

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